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    Electro spray Electro spinning Company

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    Head Office in Málaga

    C.\ Estados Unidos S/N. 29738 Rincón de la Victoria (Málaga). Spain

    Request a Quote

    Looking for a quality and affordable Company with a deep know-how and expertise in Microfluidics Techniques?

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    Phone us

    +0034 639 756 903

    Working Hours

    Monday - Thursday: 09:00 to 18:00
    Friday: 09:00 to 15:00
    Saturday - Sunday: Closed

    • svg
    • svg
    • svg

    Head Office in Málaga

    C.\ Estados Unidos S/N. 29738 Rincón de la Victoria (Málaga). Spain

    Request a Quote

    Looking for a quality and affordable Company with a deep know-how and expertise in Microfluidics Techniques?

    * Please Fill Required Fields *
    img

    Phone us

    +0034 639 756 903

    Working Hours

    Monday - Thursday: 09:00 to 18:00
    Friday: 09:00 to 15:00
    Saturday - Sunday: Closed

    Coaxial Electrospinning & Electrospraying Tech.

    DESCRIPTION

    Two liquids

    This technique enables the formation of a steady coaxial jet of two immiscible liquids by the action of the Electro-Hydrodynamic (EHD) forces. The liquids are injected through two coaxial needles connected to a HV power supply.

    Taylor cone

    Under the action of the electric field, the compound meniscus adopts a conical shape (Compound Taylor cone). An electrified coaxial jet is issued from the apex cone (diameter independent from those of the needles).The jet diameter can be tailored into the micro or nanometric size range by suitably tuning of the flow rates and liquids properties.

    DROPLETS FORMATION

    Varicose instabilities generate jet break-up producing micro-droplets. If jet solidification occurs, electrical repulsion draws the jet generating fibered core-shell capsules. Allows generating core-shell capsules from liquid solutions and dispersions.

    TWO COAXIAL NEEDLES

    The liquids are injected through two coaxial needles connected to a HV power supply.

    PROCESS STABILITY

    Can be upscaled to get to massive production. Scaling Laws of this process allows predicting the diameter and the electric current transported by the ECJ from the liquid flow rates and physical properties, which allows a good control of the process.

    This novel one-step method for microencapsulation by which core-shell nanoparticles and nanofibers are obtained (based in simple electrospraying & electrospinning techniques) is highly competitive with other existing strategies of microencapsulation based on either templates and molecular self-assembly. In fact, chemical or physical adherence onto the surface of the template depends on case-specific interactions i.e., a particular approach may not even be adaptable to the synthesis of a chemically similar material.
    “Doxa® Coaxial Electrospinning & Electrospraying Tech. is the best choice to deal with spherical or fibered micro-nanoparticles (simple/hollow/core-shell) having high loading efficiency whose shows a range of release triggers and is compatible with a wide range of active ingredients”.

    FEATURES

    The Generation and fine control of the compound jets of immiscible fluids flowing coaxially enables a full control of diameter size varying flow rate and conductivity of outer liquid. Typical diameter sizes range from 50 nanometers to 50 microns.

    This technique enables the microencapsulation in one just one step. There is no need for a freezing chamber (Spray Chilling) or drying (Spray Drying) or a chemical reactor to solidify the microcapsules. Final product is collected in the collector. This technique allows processing bioactive substances which can ́t survive at extreme conditions, e.g. heat or freezing required with other encapsulation techniques.

    Coaxial electrospray enables the production of high monodisperse droplets, the existence of satellite droplets is drastically reduced. It is ensured a low dispersion of the size of nanoparticles. As particles are electrically charged, there is a null coalescence risk. The control on the flow rate in each nozzle allows the microencapsulation of liquids with good control on the characteristics of the structure of the capsule (shell´s thickness and morphology).

    This technique shows flexibility in the production of different morphologies: Can generate fibers/particles simple, coaxial and/or hollow. The use of DOXA Multi-Injection and Continuous Collection Devices ensure the Scale-Up processes for high throughput production.

    SCOPE

    The publication in 2002 of the article “Micro/nano encapsulation via electrified coaxial liquid jets” in the Science magazine by the hand of I.G. Loscertales (Founder and CSO of Doxa®) and his team, led an incredible breakthrough in research related to the generation of micro-sized structures/nanometer both spheres shaped like fibers. 400+ citations has received this amazing scientific paper.

    This advance allowed to Doxa®, which licensed and patented the invention in 2002, began to take its first steps since numerous multinational companies (Philip Morris and Kraft) in different industries would be interested in the potential application of the technology of coaxial jets.

    One of the best reviews ever of Coaxial Electrospinning for Nanofiber Structures: Preparation and Applications Polymer Reviews, 48:353–377, 2008 by A. K. Mogue and B. S. Gupta) mentions I.G. Loscertales: “The idea of producing nanotubes using the co-axial electrospinning was first reported, by Loscertales et al. They produced ceramic and composite hollow nanofibers (silica nanotubes) by using tetraethyl orthosilicate (TEOS) as the sheath and suggested that the sheath should withstand the capillary forces during the core extraction in order to maintain the hollow fiber morphology”.

    Preparation of nanofibers in a core-sheath configuration, using two dissimilar materials, via a novel technique of co-axial electrospinning has presented unusual potential for use in many novel applications. The studies have addressed issues related to the technology involved and examined the suitability of the technique for producing unique nanoscale morphologies involving variety of materials. In this first major review of co-axial electrospinning, we provide details of the manufacturing and material factors affecting the process, the conditions needed for preparing desired uniform morphologies, and the different types of structures that have been successfully produced.

    Scientific Papers

    Parallely to the impact of the coaxial invention in the industry, for the last 20 years, a myriad of scientific papers have been supported in this technology for developing their applied research. We can cite some of the most interesting articles that have used the technique of coaxial jets.
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      Chakraborty. Electrohydrodynamics: A facile technique to fabricate drug delivery systems (Review).

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      Larsen. Use of coaxial gas jackets to stabilize Taylor cones of volatile solutions and to induce particle-to-fiber transitions.

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      Enayati. Electrohydrodynamic preparation of particles, capsules and bubbles for biomedical engineering applications.

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      He. Recent development of the nanocomposites prepared by coaxial jet technology (Review).

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      Zamani. Advances in drug delivery via electrospun & electrosprayed nanomaterials (Review).

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      Deng-Guang. Coaxial electrospinning with sodium dodecylbenzene sulfonate solution for high quality polyacrylonitrile nanofibers.

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      Thuy Thi Thu. Porous core/sheath composite nanofibers fabricated by coaxial electrospinning as a potential mat for drug release system.

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      Ghayempour. Fabrication of micro–nanocapsules by a new electrospraying method using coaxial jets and examination of effective parameters on their production.

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      Bayley. Porous microfibers by the electrospinning of amphiphilic graft copolymer solutions with multi-walled carbon nanotubes.

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      Hyun-Ha. Time-resolved high-speed camera observation of electrospray.

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      Chakraborty. Electrohydrodynamics: A facile technique to fabricate drug delivery systems.

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      Jun-He. Carbon foams from polyacrylonitrile-borneol films prepared using coaxial electrohydrodynamic atomization.

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      Bhattacharjee. Electrospinning and Polymer Nanofibers: Process Fundamentals.

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      Wongsasulak. Electrospinning of food-grade nanofibers from cellulose acetate and egg albumen blends.

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      Park. pH-responsive hydrogels from moldable composite microparticles prepared by coaxial electro-spray drying.

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      Xie. Submicron bioactive glass tubes for bone tissue engineering

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      Agarwal. Use of electrospinning technique for biomedical applications

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      Cui. Electrospun Fibers for Drug Delivery

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      Bock. Electrospraying of polymers with therapeutic molecules: State of the art

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      Woojin. Synthesis of biodegradable triple-layered capsules using a triaxial electrospray method